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Stage 3 Mesothelioma

Stage 3 mesothelioma is considered advanced. At this point, the cancer has spread beyond the original tumor site and into the lymph nodes. However, it is still contained in 1 side of the body.

Stage 3 Symptoms

  • Chest pain becomes more painful.
  • Fluid develops in the abdomen.
  • There is unexplained weight loss.
  • A lump may develop in the chest or abdominal area.

It is more common for mesothelioma to be diagnosed in stages 3 and 4 than in the earlier stages. This is because the symptoms in the advanced stages are more severe.


For most stage 3 mesothelioma patients, the cancer has advanced too far to be completely removed from the body. Surgery may still be an option, but it is usually performed to relieve symptoms and possibly to extend the patient’s life.

Whether or not surgery is an option is based on several factors:

  1. The cell subtype of the tumor—most doctors believe the surgical removal of sarcomatoid tumors is not an effective treatment.
  2. Extent of tumor growth—how far has the tumor grown into nearby tissues?
  3. Location of the tumor—how close is the tumor to any vital organs?
  4. General health of the patient—the person must be strong enough to make it through the procedure.

Stage 3 Mesothelioma

  • Mesothelioma is localized and affects the lining of the chest wall
  • The cancer might also affect the pleural lining of the diaphragm (the breathing muscle) or the mediastinum (the space between the lungs)
  • Has not yet spread to the lymph nodes or others parts of the body

Treatment Options

Palliative surgery (benefits: symptom relief)

Palliative surgery can be performed to help stage 3 mesothelioma patients get much-needed relief from their uncomfortable symptoms, including painful breathing. Any of the 3 types of surgery that are typically prescribed in an effort to save the lives of stage 1 or 2 patients can now be recommended for symptom relief. These surgeries are:

In addition, 3 other surgical procedures can be performed to remove the fluid that has built up around a tumor and is causing painful symptoms. While these procedures help provide symptom relief, they may need to be repeated if the fluid builds up again. These procedures are:

  • Pleurodesis – This procedure is done as a preventative measure to try to keep fluid from building up in the chest. A doctor makes a small incision in the outside of the chest wall and inserts a hollow tube (called a chest tube). Then, the fluid is drained. The tube is usually left inside the patient’s body for 1 or 2 days to prevent additional fluid build-up.
  • Shunt placement – The shunt is a medical device made up of a long, thin, flexible tube with a small pump in the middle. The shunt is used to move fluid from one part of the body to another. A pleuro-peritoneal shunt allows fluid in the chest to move into the abdomen, where it can be absorbed by the body. Placing a shunt requires an operation in which a doctor inserts one end of the shunt into the chest wall and the other end into the abdomen. Once the shunt is in position, the patient uses the pump several times a day to remove fluid from the chest. This procedure may be performed if pleurodesis or other techniques are not effective.
  • Catheter placement – A catheter is a thin, flexible tube. In a procedure performed in a doctor’s office or a hospital setting, a doctor inserts one end of the catheter into the patient’s chest or abdomen through a small incision in the skin. The other end of the catheter remains outside the body, where it is attached to a special device that collects fluid as it drains.


Radiation is used to slow cancer down or to control symptoms. It is usually used in combination with surgery and chemotherapy. The length of treatment depends on the type, size, and stage of mesothelioma. Radiation is sometimes given after fluid has been drained from around the lung. This procedure is meant to prevent new mesothelioma tumors from developing on the chest wall.


This treatment is given to help control symptoms and to try to slow the cancer down. The chemotherapy process typically involves intravenous delivery of anti-cancer drugs. For pleural mesothelioma, however, chemotherapy drugs may be injected directly into the pleural space around the lungs (intrapleurally). Depending on the type of chemotherapy drugs used, this treatment can be prescribed weekly or every 2 to 3 weeks.

Clinical trials

For some mesothelioma patients, participating in a clinical trial may be an appropriate treatment option. Clinical trials are part of the cancer research process. These studies are designed to find out whether new cancer treatments are safe and effective and possibly better than the existing options. Many of today’s most effective treatments were developed in earlier clinical trials.

For more information about clinical trials for mesothelioma patients, visit these sites: