Mesothelioma Treatment

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Doctors put mesothelioma patients on targeted and tailored treatment plans. Mesothelioma patients may undergo surgery, chemotherapy, radiation therapy or a combination of all three to aggressively target, shrink and remove tumors.

Mesothelioma Treatments Overview

While there is no cure for mesothelioma, life-extending treatments are available for patients at every stage. New therapies being tested in clinical trial settings also offer valuable, potentially life-prolonging options for many mesothelioma patients.

Here’s an overview of what mesothelioma patients should know about their treatment options:

  • Standard treatment options are surgery, chemotherapy and radiation therapy
  • Doctors tailor treatments to each unique case
  • All patients have treatment options no matter their condition
  • Many treatments can significantly improve prognosis and extend the lifespan
  • Patients may receive treatment at cancer centers from specialized doctors
  • Receive our FREE Mesothelioma Help Guide for more information on all available treatments options

How Do Mesothelioma Treatments Work?

There is one common goal of mesothelioma treatment: to prevent the growth and spread of the cancer throughout the body.

Mesothelioma treatments include:

  • Removing tumors from the abdomen, lungs or heart
  • Shrinking the size of tumors
  • Killing cancer cells to prevent them from multiplying
  • Preventing tumors from spreading to the lymph nodes (the immune system’s filters)
  • Reducing abdominal and chest pressure
  • Alleviating painful symptoms and improving comfort levels (palliative)

How treatments work depends on the type of mesothelioma and how far it has spread.

Early-Stage Treatment

In earlier stages, mesothelioma treatments are often aggressive and require surgery to cut into the affected area and remove the tumor. These treatments are often followed up with chemotherapy or radiation to kill off any remaining cancer cells that may have been missed.

What Can I Expect During Treatment?

As long as patients are being treated by mesothelioma specialists, they can expect to receive high quality care. Top mesothelioma doctors work at specialized cancer centers across the country.

At these cancer centers, a team of medical professionals will review the individual patient’s case and place them on a tailored treatment plan.

Mesothelioma patients can expect to be well taken care of at these premier cancer centers. Oncologists, pathologists, radiologists and additional specialists are all part of the care process.

Depending on the type of treatment, mesothelioma patients should be prepared to receive treatment at the cancer center for several weeks. Surgery requires time for preparation and recovery, and chemotherapy requires consistent and regular visits over the course of several weeks.

Before receiving treatment, a patient’s medical team explain in detail what they can expect, including potential side effects and reactions. Patients will be monitored through all in-hospital care, and doctors will also provide assistance with the recovery process.

Find the Right Specialist for Your Diagnosis

Mesothelioma doctors across the country are accepting new mesothelioma patients now. Our Doctor Match Program connects you with a nearby specialist to help improve your prognosis.

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What Types of Mesothelioma Treatments Are Available?

Mesothelioma patients today have several important and life-saving options for treatments. With new therapies undergoing clinical trials, patients have access to cutting-edge mesothelioma treatments that can dramatically improve their prognosis.

The three standard mesothelioma treatment options are:

  1. Surgery: Targeted, specialized surgical procedures designed to remove mesothelioma tumors from the lungs, abdomen or heart.
  2. Chemotherapy: High-potency anti-cancer drugs that circulate through the bloodstream, killing off mesothelioma cells.
  3. Radiation Therapy: High-intensity energy rays aimed at mesothelioma tumors to shrink them in size.

Doctors often combine these options to provide the most well-rounded treatment plan. Aggressive treatments combining two or more approaches have proven to have the highest level of success in mesothelioma patients.

Pleural Mesothelioma Treatments

Pleural mesothelioma treatments typically involve aggressive surgical procedures, combined with multiple rounds of chemotherapy drugs.

Pleural Mesothelioma Surgery Update

The goal of pleural mesothelioma treatment is to remove as much of the tumor from the lung lining and chest cavity as possible. Then, doctors administer chemotherapy to kill remaining mesothelioma cells.

The two most commonly performed pleural mesothelioma surgeries are:

  • Extrapleural Pneumonectomy (EPP): Doctors remove the affected lung and the pleura lining around the chest. They may also remove part of the pericardium (heart lining) and diaphragm. Though this procedure involves the patient living with only one lung, it is considered one of the best solutions for minimizing the spread of mesothelioma and ultimately giving the patient a greater chance at survival.
  • Pleurectomy/Decortication (P/D): In contrast to the EPP procedure, pleurectomy with decortication is a lung-saving surgery. It involves removing the diseased pleura that lines the lungs and chest wall. Doctors who specialize in P/D procedures believe it is a better alternative to EPP because it allows the patient to keep their lung.

Peritoneal Mesothelioma Treatments

Peritoneal mesothelioma treatment often involves multiple phases. Doctors may begin by administering radiation therapy to shrink tumors in size, then move on to surgery to remove the shrunken tumors. Removing as much of the tumor as possible gives the patient a greater chance at survival because it slows down or stops the spread (metastasis) of mesothelioma.

Did You Know

The most aggressive and effective peritoneal mesothelioma surgical procedure is cytoreduction with HIPEC. Cytoreduction is the process of debulking the abdominal cavity from tumors. Doctors then administer HIPEC (heated chemotherapy drugs) directly into the open abdominal cavity post-surgery. The drugs circulate through the abdomen, covering the organs in anti-cancer drugs until leftover cells have been killed.

Typical rounds of treatment finish with further radiation or chemotherapy to destroy the remaining cancer cells.

Pericardial Mesothelioma Treatments

Pericardial mesothelioma is the hardest form of mesothelioma to treat due to its proximity to the heart and the risk this poses.

Pericardial mesothelioma is the most challenging form of mesothelioma to treat due to its proximity to the heart. Most pericardial mesothelioma patients just receive chemotherapy because surgery close to the heart is too risky. Some patients also receive radiation therapy to shrink tumors in the heart’s lining and surrounding areas.

In rare cases, doctors will perform a pericardiectomy to remove the lining of the heart (pericardium). This reduces inflammation and pressure caused by the constriction of the diseased pericardium.

What Treatments Are Right for Your Mesothelioma Diagnosis?

Specialists agree a personal treatment plan is the key to improving prognosis. The Mesothelioma Help Guide assists patients in understanding their diagnosis and offers the best treatment options.

Request Your Free Mesothelioma Help Guide Now

Follow-Up Mesothelioma Care

Follow-up care is an essential aspect of mesothelioma treatment. Doctors are committed to monitoring their patients closely after successful treatments.

Today, many doctors treat mesothelioma cases like a chronic disease. After successful treatment through surgery, chemotherapy and/or radiation therapy, doctors remain focused on keeping the mesothelioma under control and managing their patient’s condition.

Living with mesothelioma can be difficult and stressful for patients and their families. Mesothelioma patients may also experience a recurrence, meaning their cancer comes back after successful treatment.

However, by regularly following up with their doctors, patients can receive the best care possible and receive proper care if their cancer returns.

Deciding on Mesothelioma Treatments

Doctors ultimately determine which treatments are the best for each mesothelioma patient. They consider many factors when treating patients, as not all treatments work for all cases.

Here are some of the aspects doctors take into account when determining appropriate mesothelioma treatments:

  • Mesothelioma location
  • Mesothelioma stage
  • Patient’s age
  • Patient’s overall health level
  • Previous patient responses to treatments

How far the mesothelioma has advanced is one of the most important factors doctors consider when developing a treatment plan. Doctors usually consider patients with early stage mesothelioma to be excellent candidates for invasive surgery to remove tumors or even entire organs.

In some cases, even patients with end-stage mesothelioma can be good candidates for surgical procedures. However, the treatment goals and expected outcomes may be different.

Patient health is another one of the most critical factors doctors consider when developing a treatment plan. Patients with poor health may not be able to withstand the side effects or possible complications involved with surgery, radiation or chemotherapy.

Personalized Treatment Plans

If you’ve been diagnosed with mesothelioma, ask your mesothelioma specialist and health care team about personalized treatments. It’s necessary to take an active role in your treatment decisions to ensure you’re being placed on a targeted care plan.

Treatments Are Unique

Treatments are not a one-size-fits-all solution. Instead, treatments must be highly personalized to each patient to ensure the most accurate approach and the highest chance of success. It’s vital for mesothelioma patients to work with doctors and health care teams that believe in personalized treatments. 


Mesothelioma specialists are advocates and champions for specialized treatments tailored to each patient.

Personalized treatment plans should always consider your mesothelioma location, stage and cell type. They should also include multiple stages of treatment, including neoadjuvant and adjuvant treatments (treatments administered before and after surgery to shrink tumors and/or kill remaining cancer cells).

Get Matched With a Mesothelioma Doctor Today

Register for our FREE Doctor Match Program today to be connected with a doctor specializing in your exact diagnosis.

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How Can I Manage My Mesothelioma Symptoms?

Pain caused by the effects of mesothelioma can often be uncomfortable and unbearable. It’s critical that patients communicate clearly with their doctors about the symptoms they’re experiencing.

All patients experience pain during their battle with mesothelioma. Chronic pain in the back and chest is common. It’s also normal for mesothelioma patients to lose their appetite and as a result go through severe weight loss. These symptoms and complications should be addressed so that patients can improve their quality of life.

Doctors can use the following to manage symptoms of mesothelioma:

  • Pain medications
  • Palliative surgery
  • Radiation
  • Physical therapy
  • Natural and complementary therapies

Emotional Wellness Update

An important aspect of symptom management is also emotional wellness. It’s common for patients to feel stressed and anxious during their battle against mesothelioma. Alternative therapies for stress reduction including acupuncture, massage therapy and holistic medicine have all shown to complement standard treatments well.

What are the New Mesothelioma Therapies?

Research into mesothelioma treatments is currently underway to find and develop new and cutting-edge therapies. While it is a lengthy process to have treatments approved by government agencies, patients can still access them through clinical trials.

Mesothelioma researchers are currently developing the following types of experimental treatments:

Many of these new therapies, drugs and treatment approaches have proven to be successful in clinical trial settings. Mesothelioma patients who participate in these clinical trials may be able to improve their initial prognosis if other treatments do not.

New Mesothelioma Treatment Update

Biologic therapy is a new treatment currently being investigated through clinical trials. Also called immunotherapy, it uses the patient’s immune system to fight mesothelioma.

Experimental therapies can give patients new hope. In some cases, patients may stop responding to treatments and feel as though they’ve exhausted their options. By participating in clinical trials, patients can have new opportunities to improve their prognosis and quality of life.

How Can I Participate in a Clinical Trial?

Many end-stage or non-responsive patients are good candidates for clinical trials. Doctors and mesothelioma specialists are the best sources for connecting with ongoing clinical trials.

Mesothelioma specialists often recommend clinical trials to their patients who are considered good candidates for the particular therapy. Patients can also ask their doctors about how to participate in a clinical trial. Doctors and cancer center staff help patients get connected with clinical trials seeking participants.

Clinical Trial Update

Clinical trials take place at cancer centers and medical schools across the country and around the world. To date, there have been over 250 mesothelioma clinical trials conducted globally.

To participate in a clinical trial, patients need to travel to the trial location to undergo treatment. Clinical trials are safe, controlled environments led by scientists dedicated to finding the best possible mesothelioma treatment solutions.

All mesothelioma patients deserve a specialized and tailored treatment plan. Call us today at (800) 584-4151 or receive a FREE Mesothelioma Help Guide to understand your treatment options that can help improve your prognosis.

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Sources
  1. American Cancer Society, “What Happens After Treatment for Malignant Mesothelioma?” Retrieved from: https://www.cancer.org/cancer/malignant-mesothelioma/after-treatment/follow-up.html. Accessed on November 7, 2017.
  2. American Cancer Society, “Treating Malignant Mesothelioma.” Retrieved from: https://www.cancer.org/cancer/malignant-mesothelioma/treating.html. Accessed on November 7, 2017.
  3. Mesothelioma Applied Research Foundation, “Mesothelioma Treatment and Recovery Scenarios.” Retrieved from: http://www.curemeso.org/site/c.duIWJfNQKiL8G/b.8578141/k.362E/Mesothelioma_Treatment_and_Recovery_Scenarios.htm. Accessed on November 7, 2017.
  4. Mesothelioma Applied Research Foundation, “Mesothelioma Clinical Trials | Treatments for Mesothelioma.” Retrieved from: http://www.curemeso.org/site/c.duIWJfNQKiL8G/b.8578127/k.A0E3/Mesothelioma_Clinical_Trials__Treatments_for_Mesothelioma.htm. Accessed on November 7, 2017.

Last modified: June 20, 2019